Acta Physiol News Today

Measurement of gene expression in the brain requires invasive analysis of brain tissue or non-invasive methods that are limited by low sensitivity. Here we introduce a method for non-invasive, multiplexed, site-specific monitoring of endogenous gene or transgene expression in the brain through engineered reporters called released markers of activity (RMAs). RMAs consist of an easily detectable reporter and a receptor-binding domain that enables transcytosis across the brain endothelium. RMAs are...

The aim of this review is to critically summarize experimental and clinical data of fibroblast growth factor-21 in nonalcoholic fatty liver disease.

When you read about people dying of “natural causes,” it usually means that they died of heart failure ...

Tea is a steeped beverage made from the leaves of Camellia sinensis. Globally, this healthy, caffeine-containing drink is one of the most widely consumed beverages. At least 50 countries produce tea and most of the production information and tea research is derived from international sources. Here, we discuss information related to tea production, genetics, and chemistry as well as production issues that affect or are likely to affect emerging tea production in the USA. With this review, we rela...

Reviewing the effect of metabolites on mitochondrial functions in the pathogenesis of skeletal muscle aging. Read more

Reviewing the relationship between iron overload and diabetes and its relationship with LEAD, and discussing its mechanism from various aspects.

Aging causes you to lose strength, no matter how much you exercise. Muscles are made up of hundreds ...

Children recover faster than adults in repeated sprints, but it is unclear if their aerobic responses differ. Purpose: This study tested the hypothesis that aerobic response (VO2) during repeated sprints is greater in preadolescent boys than in men. Further, this study compared normalization with conventional ratio-scaling and scaling with the use of body mass as a covariate. Methods: Nine boys (age: 11.8 ± 0.6 years, swimmers) and 11 men (age: 21.7 ± 0.6 years, recreational athletes) ...

Cardiovascular disease (CVD) and stroke affect over 92 million Americans and account for nearly 1 out of 3 deaths in the US. The use of animal models in cardiovascular research has led to considerable advances in treatment and in our understanding of the pathophysiology of many CVDs. Still, animals may not fully recapitulate human disease states; species differences have long been postulated to be one of the main reasons for a failure of translation between animals and humans in drug discovery a...