Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus elifesciences.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from elifesciences.org Daily Mail and Mail on Sunday newspapers.
Despite the considerable efficacy observed when targeting a dispensable lineage antigen, such as CD19 in B cell acute lymphoblastic leukaemia1,2, the broader applicability of adoptive immunotherapies is hampered by the absence of tumour-restricted antigens3–5. Acute myeloid leukaemia immunotherapies target genes expressed by haematopoietic stem/progenitor cells (HSPCs) or differentiated myeloid cells, resulting in intolerable on-target/off-tumour toxicity. Here we show that epitope engineering of donor HSPCs used for bone marrow transplantation endows haematopoietic lineages with selective resistance to chimeric antigen receptor (CAR) T cells or monoclonal antibodies, without affecting protein function or regulation. This strategy enables the targeting of genes that are essential for leukaemia survival regardless of shared expression on HSPCs, reducing the risk of tumour immune escape. By performing epitope mapping and library screenings, we identified amino acid changes that abr
Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.
In this application compendium, Agilent Technologies introduces the use of its Fragment Analyzer Systems for nucleic acid analysis and sample quality assessment. The Fragment Analyzer Systems offer a wide range of application kits, enabling easy sizing, qualification, and quantification of both DNA and RNA samples. Additionally the compendium also provides a brief overview of capillary electrophoresis technology and the product portfolio of Fragment Analyzer Systems.