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Owners of San Francisco's commercial real estate are deciding to give up once trophy properties rather than count on a revival of the city's downtown.

The number of publicly traded U.S. companies has fallen by more than half since 1996, according to data from the Center for Research in Security Prices.

Even buyers who can afford high home prices are dropping out as competition intensifies. "I'm done with this market," one customer told his lender.

Real-estate investors are turning down more fix and flip opportunities because they don't pencil out, said Toorak Capital Partners CEO John Beacham.

Thomas Baltimore, the CEO of Park Hotels & Resorts, said the hotels have become a burden to the company as remote work clears out the city's offices.

Office delinquencies soared in April, hitting the "tipping point" that investors have predicted, according to Trepp. Opportunistic buyers lie in wait.

An index showed prices fell across all types of commercial real estate in April, year-over-year, the first time that's happened since September 2010.

Subway pushings and other assaults have led to an increased police presence, though that hasn't been enough to fix the problem, a riders' group said.

Recent bank failures magnified risks of commercial real estate, which is also grappling with higher borrowing costs on the heels of Fed rate hikes.