Alectin 3 News Today

MyJournals.org - Science - IJMS, Vol. 24, Pages 8116: Development of Galectin-3 Targeting Drugs for Therapeutic Applications in Various Diseases (International Journal of Molecular Sciences)

MyJournals.org - Science - IJMS, Vol. 24, Pages 7683: Galectin-3 as a Marker for Increased Thrombogenicity in COVID-19 (International Journal of Molecular Sciences)

Human galectin-3 (hGal-3) is involved in a variety of biological processes and is implicated in wide range of diseases. As a result, targeting hGal-3 for clinical applications has become an intense area of research. As a step towards the development of novel hGal-3 inhibitors, we describe a study of the binding of two Se-containing hGal-3 inhibitors, specifically that of di(β-D-galactopyranosyl)selenide (SeDG), in which two galactose rings are linked by one Se atom and a di(β-D-galactopyranosy...

Environmentally-mediated drug resistance in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) significantly contributes to relapse. Stromal cells in the bone marrow environment protect leukemia cells by secretion of chemokines as cues for BCP-ALL migration towards, and adhesion to, stroma. Stromal cells and BCP-ALL cells communicate through stromal galectin-3. Here, we investigated the significance of stromal galectin-3 to BCP-ALL cells. We used CRISPR/Cas9 genome editing to ablate galecti...