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Monoclonal antibodies against MERS coronavirus show promise in phase 1 NIH-sponsored trial

Credit: NIAID and Colorado State University WHAT: A randomized, placebo-controlled Phase 1 clinical trial of two monoclonal antibodies (mAbs) directed against the coronavirus that causes Middle East respiratory syndrome (MERS) found that they were well tolerated and generally safe when administered simultaneously to healthy adults. The experimental mAbs, REGN3048 and REGN3051, target the MERS coronavirus (MERS CoV) spike protein used by the virus to attach to and infect target cells. The mAbs w...
New York United States College Park Annea Oplinger University Of Maryland National Institute Of Allergy

Results of NIH-sponsored ACTIV-3 trial published

 E-Mail IMAGE: Colorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (orange), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF)... view more  Credit: NIAID Preliminary results of a phase 3, randomized, placebo-controlled clinical trial testing the investigative monoclonal antibody LY-CoV555 in hospitalized COVID-19 patients were published today in the New England Journal of Me...
British Columbia United States Annea Oplinger James Neaton Alan Moskowitz Taylor Thompson

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