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24-hour delay may be safe for surgical intervention in patients with uncomplicated appendicitis

1. Operating within 24 hours was non-inferior to operating within 8 hours among patients diagnosed with uncomplicated appendicitis with respect to the risk of appendiceal perforation. 2. There were no reported deaths in either group. Evidence Rating Level: 1 (Excellent) Study Rundown: Appendicectomy, or appendectomy, is the standard treatment for appendicitis, yet no consensus exists
Rating Level Randomized Trial Comparing Antibiotics Between May Appendiceal Perforation Complicated Appendicitis General Surgery

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Sacituzumab govitecan shows survival benefit in endocrine-resistant hormone-positive metastatic breast cancer

1. Median overall survival increased by 3.2 months in the sacituzumab govitecan group compared to chemotherapy. 2. One fatal treatment-related adverse event was reported in the sacituzumab group. Evidence Rating Level: 1 (Excellent) Study Rundown: In phase 3 of the TROPiCS-02 trial, sacituzumab govitecan demonstrated significant survival benefit versus chemotherapy among patients with hormone-receptor-positive (HR+)
United States Sacituzumab Govitecan Rating Level Metastatic Triple Negative Breast Between May North America

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