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1. Significantly more patients in the bimekizumab group than placebo reported improved clinical response at week 16. 2. Treatment-related adverse events were infrequent with one fatality across both treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Hidradenitis suppurativa (HiS) is a chronic inflammatory disease with limited therapeutic options. Bimekizumab, a monoclonal IgG1 antibody that

1. In this cohort study of families with suspected Mendelian disorders for whom preliminary genetic testing had not revealed a diagnosis, nearly one-third of families obtained a plausible molecular diagnosis after genome sequencing. 2. While enhancing prior exome sequencing likely would have revealed the causal variants in most cases, over one-quarter of the new diagnoses

1. In this randomized controlled trial, adults with mixed hyperlipidemia who received zodasiran had dose-dependent decreases in triglyceride levels compared to those who received placebo. 2. Patients who received the highest dose of zodasiran had transiently increased glycated hemoglobin levels, returning to baseline with treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Mixed hyperlipidemia is

1. In this randomized controlled trial, aficamten significantly improved peak oxygen uptake in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) compared with placebo. 2. The results for all 10 secondary endpoints were significantly improved with aficamten. Evidence Rating Level: 1 (Excellent) Study Rundown: HCM is one of the most common genetic heart diseases and is

1. Women in the surgical group reported 2.5 times more spontaneous ovulations than in medical therapy. 2. Those assigned to surgery had a higher rate of adverse events, although none led to long-term issues. Evidence Rating Level: 1 (Excellent) Study Rundown: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and obesity

1. In this retrospective cohort study, among patients with type 2 diabetes (T2D) and stage five chronic kidney disease (CKD), the use of a sodium-glucose cotransporter-2 inhibitor (SGLT2i) was associated with a lower risk of dialysis, cardiovascular events, diabetic ketoacidosis (DKA), and acute kidney injury (AKI). 2. SGLT2i use was not associated with a difference

1. In this randomized controlled trial, it was found that those who received transcatheter aortic valve replacement (TAVI) did not have an increased risk of stroke and all-cause mortality compared to those who received surgical replacement (SAVR). 2. Those who underwent a transcatheter procedure had significantly fewer major bleeding events compared to those who underwent

1. There was no significant difference in metastasis-free survival between the ADT and non-ADT groups over 10 years. 2. Adverse events were comparable between both groups and no fatalities were reported. Evidence Rating Level: 1 (Excellent) Study Rundown: Short-term androgen deprivation therapy (ADT) with primary adjuvant radiotherapy is known to improve metastasis-free survival in patients

1. Adults with chronic low back pain (CLBP) randomized into a 6-week pain intervention education program were observed to have significantly relieved burden of pain-related disability and overall pain intensity when combined with the physiotherapeutic standard of care. 2. Measures of self-reported well being also improved significantly more in the pain education group compared to