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Bimekizumab safe and effective for treatment of moderate-to-severe hidradenitis suppurative

1. Significantly more patients in the bimekizumab group than placebo reported improved clinical response at week 16. 2. Treatment-related adverse events were infrequent with one fatality across both treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Hidradenitis suppurativa (HiS) is a chronic inflammatory disease with limited therapeutic options. Bimekizumab, a monoclonal IgG1 antibody that
United States Hidradenitis Suppurativa Rating Level Between Feb

Bariatric surgery may improve rates for spontaneous ovulation in patients with polycystic ovarian syndrome and obesity

1. Women in the surgical group reported 2.5 times more spontaneous ovulations than in medical therapy. 2. Those assigned to surgery had a higher rate of adverse events, although none led to long-term issues. Evidence Rating Level: 1 (Excellent) Study Rundown: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and obesity
United Kingdom Lifestyle Program In Obese Infertile Women Rating Level Randomized Trial Lifestyle Program Obese Infertile

Typhoid conjugate vaccine shows promising long-term efficacy in children

1. Children randomized to the MenA group rather than the Vi-TT group were more likely to be diagnosed with typhoid fever. 2. Overall Vi-TT vaccine efficacy was 78.3% with the highest efficacy seen for children aged 2-4 years. Evidence Rating Level: 1 (Excellent) Study Rundown: Typhoid conjugate vaccines in Africa and Asia have shown high
Rating Level Typhoid Conjugate Vaccine Between Feb Global Health Public Health Typhoid Fever

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Colchicine does not reduce risk of atrial fibrillation or myocardial injury after non-cardiac surgery

1. Colchicine did not significantly reduce the risk of atrial fibrillation or myocardial injury after non-cardiac surgery. 2. Use of colchicine was associated with a higher incidence of non-infectious diarrhea. Evidence Rating Level: 1 (Excellent) Study Rundown: Colchicine is an anti-inflammatory drug that may be used for the management of gout and pericarditis. Patients with
Rating Level Low Dose Colchicine Between Feb Atrial Fibrillation Cardiac Events Myocardial Injury After Non Cardiac Surgery Mins

Opioid analgesia may be ineffective for acute low back and neck pain

1. Mean pain score at 6 weeks was not statistically different between the opioid and placebo groups. 2. Risk of opioid misuse after 52 weeks was higher in the opioid group compared to the placebo group. Evidence Rating Level: 1 (Excellent) Study Rundown: Opioid analgesics are commonly used for acute low back and neck pain,
New South Wales Rating Level Brief Pain Inventory Reducing Opioid Use Chronic Pain With Between Feb

Once-a-month fitusiran reduces bleeding rates in patients with hemophilia A and B with inhibitors

1. Annualized bleeding rate was reduced by 91% in the fitusiran prophylaxis group compared to the bypassing agents on-demand group. 2. 5% of patients in the fitusiran group reported thromboembolic events; there were no deaths. Evidence Rating Level: 1 (Excellent) Study Rundown: Hemophilia is marked by a deficiency in certain coagulation factors that make patients
Rating Level Efanesoctocog Alfa Prophylaxis Severe Hemophilia Between Feb Hemophilia A Hemophilia B

Endovascular therapy improved clinical outcomes among patients 6-24 hours post-ischemic stroke with collateral flow

1. Median modified Rankin Scale score at 90 days was lower in the endovascular group, indicating improved outcomes. 2. Symptomatic intracranial bleeding was more prominent in the intervention group than control. Evidence Rating Level: 1 (Excellent) Study Rundown: Previous guidelines support the use of endovascular treatment for patients with anterior circulation artery-related ischemic stroke within
National Institutes Of Health Stroke Scale Rankin Scale Rating Level Endovascular Thrombectomy Large Ischemic Between Feb

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