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Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Using antigenic cartography, researchers analyzed cross-reactivity patterns of SARS-CoV-2 variants and the effect of spike-protein changes on post-infection and vaccination immune responses. The study illuminated unique neutralization profiles and underscored the evolving defense mechanisms with repeated immunizations.
Drug Administration World Health Organization Institutional Review Board Coronavirus Efficacy Geometric Mean Titers Binding Domain

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Development of a novel surface plasmon resonance-based assay to determine kinetics of SARS-CoV-2 spike – human ACE2 interaction

A team of scientists has recently studied the kinetic and thermodynamic characteristics of interaction between human ACE2 and spike receptor-binding domains of different variants of SARS-CoV-2.
Kateryna Kon Shutterstock Research Square World Health Organization Interactions Between Common Variants Binding Domain Coronavirus Disease Covid 19

Frontiers | Molecular Docking and Dynamics Studies to Explore Effective Inhibitory Peptides Against the Spike Receptor Binding Domain of SARS-CoV-2

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic due to the high transmission and mortality rate of this virus. The world health and economic sectors have been severely affected by this deadly virus, exacerbated by the lack of sufficient efficient vaccines. The design of effective drug candidates and their rapid development is necessary to combat this virus. In this study, we selected 23 antimicrobial peptides from the literature and predicted thei...
Saudi Arabia United States San Diego J Neuroimmune Pharmacol Albiol Matanic Dermatophagoides Pteronyssinus

New vaccine candidate could be a cost-effective option against emerging SARS-CoV-2 variants

New vaccine candidate could be a cost-effective option against emerging SARS-CoV-2 variants A multidisciplinary team of researchers is the first to show combining yeast-expression technology and a novel adjuvant formulation to produce a COVID-19 vaccine candidate is effective against SARS-COV-2 and promises to be easy to produce at large scale and cost-effective, important aspects for vaccinating people worldwide, especially in low- to middle-income countries. Results from the study, which appl...
Baylor College Of Medicine United States Rafickp Sekaly Sudhir Kasturi Emily Henderson Peter Hotez

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