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Ibrutinib Plus Venetoclax With MRD-Directed Duration of Treatment Is a New Standard of Care Regimen for Previously Untreated CLL

This is the first trial to show that a MRD-guided approach with treatment beyond MRD negativity has a significant advantage over chemotherapy, both in terms of PFS and OS.
United Kingdom United States American Society Of Hematology University Of Leeds International Workshop On Chronic Lymphocytic Leukemia Peter Hillmen

Phase 3 CLL12 Data Support Watch-and-Wait Approach in Early-Stage CLL

Ibrutinib did not prolong survival vs placebo and is linked with increased susceptibility to bleeding in patients with asymptomatic early-stage chronic lymphocytic leukemia, suggesting that a watch-and-wait approach should continue as the standard for this population.
Petra Langerbeins Ibrutinib Imbruvica University Of Cologne Division Of Haematology Binet Stage Intensive Care

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