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Multiple KRAS targeting strategies paving way for combination therapies

KRAS-mutated tumors were once untreatable. In fact, KRAS was something of a poster child for so-called undruggability. Several laboratories are investigating strategies to address other mutations and uses beyond non-small cell lung cancer (NSCLC) and colorectal cancer. If you cant bind KRAS to block it, use a glue or combine multiple weapons. This is the idea behind two new approaches that target cancers caused by this proto-oncogene.
Kras G12c Pan Kras Cyclophilin A Cd8t Cells University Of Texas Md Anderson Cancer Center Memorial Sloan Kettering Cancer Center

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Lasting immunity found after recovery from COVID-19

At a Glance The immune systems of more than 95% of people who recovered from COVID-19 had durable memories of the virus up to eight months after infection. The results provide hope that people receiving SARS-CoV-2 vaccines will develop similar lasting immune memories after vaccination. Colorized scanning electron micrograph of a cell, isolated from a patient sample, that is heavily infected with SARS-CoV-2 virus particles (red). NIAID Integrated Research Facility, Fort Detrick, Maryland After p...
United States Fort Detrick Daniela Weiskopf Shane Crotty Alessandro Sette Sharon Reynolds
Source: nih.gov

Virus Variants Can Resist Antibodies. And More News Straight from Science Journals

The latest roundup of pandemic findings gathered by Hakai Magazine. Brian Owens 9 Mar 2021 | Hakai Magazine Brian Owens is a freelance science writer and editor based in St. Stephen, New Brunswick. His work has appeared in Hakai Magazine, Nature, New Scientist, the Canadian Medical Association Journal and the Lancet. SHARES A mass COVID-19 vaccination centre in Peel, Ont. prepares for the day. New research shows vaccines may need to be regularly updated to keep up...
United States South Africa United Kingdom San Francisco Brian Owens Hakai Magazine
Source: thetyee.ca

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