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What Makes Us Human? This Often Overlooked DNA May Provide Answers

Human DNA is remarkably similar to that of the chimpanzee, our closest living relative in evolutionary terms. However, researchers from Lund University in Sweden have discovered a previously unknown portion of human DNA, known as non-coded DNA, that appears to contribute to a distinction that, despite our similarities.
United States Shinya Yamanaka Johan Jakobsson Lund University Cell Stem Homo Sapiens

Human and Chimp Brains Differ in Non-Coding Regulatory DNA

Stem cell researchers at the Lund University, Germany, identify ZNF558, a transcription factor expressed in human but not chimpanzee forebrain progenitors cells, that regulates mitochondrial function and determines the timing of early human brain development. The authors show this transcription factor regulates a gene called SPATA18 that regulates the selective degradation of mitochondria. The expression of ZNF558 is controlled by the size of a structural repeat in noncoding DNA that is longer i...
United States Johan Jakobsson Lund University Cell Stem

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