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Key Biomarkers for Prediction Response to Melanoma Therapy identified

Using advanced computing technology scientists at the Wistar Institute (Philadelphia) have been able to provide evidence of novel, reliable biomarkers that better predict therapy response of patients undergoing immune checkpoint inhibitor (ICI) treatment. Click to read more...
Noam Auslander Andrew Patterson Ronald Caplan Cancer Centre Wistar Institute Philadelphia Molecular Cellular Oncogenesis Program Of Wistar Ellen Wistar Institute

Research uncovers novel predictors of immune checkpoint inhibitor therapy for melanoma

Immune checkpoint inhibitor (ICI) therapy is a type of treatment for melanoma, the deadliest form of skin cancer, which blocks proteins on tumor or immune cells that prevent the immune system from killing cancer cells.
Noam Auslander Andrew Patterson Emily Henderson Nature Communications Ronald Caplan Cancer Center Molecular Cellular Oncogenesis Program Of Wistar Ellen

Potential tumor vulnerability may be exploited to improve treatment of neuroblastoma

A Ludwig Cancer Research study has identified a potential vulnerability in neuroblastoma tumors that might be exploited to improve treatment of the aggressive childhood cancer, which accounts for roughly 15% of all deaths from pediatric malignancies.
United States Adam Wolpaw Chi Van Dang Emily Henderson Molecular Cellular Oncogenesis Program Proceedings Of The National Academy Sciences

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Research at Penn Medicine Led by Indian American Prof. Ravi Amaravadi Receives $11.7 M National Cancer Institute Grant

Indian American-led research from Penn Medicine and The Wistar Institute has been awarded a prestigious $11.7 million Specialized Programs of Research Excellence, or SPORE, grant from the National Cancer Institute.
Ravik Amaravadi Meenhard Herlyn National Cancer Institute Perelman School Of Medicine Wistar Melanoma Research Center Abramson Cancer Center

Alternative cancer cell fuel source targeted as therapeutic approach for breast cancer

ย E-Mail IMAGE:ย Wistar scientists characterized an inhibitor that targets acetate metabolism in cancer cells. This molecule caused tumor growth inhibition and regression in preclinical studies, demonstrating the promise of this approach as... view moreย  Credit: The Wistar Institute PHILADELPHIA -- (Jan. 7, 2021) -- Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in...
United States Joel Cassel Susang Komen Sara Papp Joseph Salvino Yellamellivv Srikanth

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