Molecular Cellular Oncogenesis Program News Today

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it.

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

Investegate announcements from The Wistar Institute, Wistar Scientists Identify a Gene Signature to Assess Cancer Risk in People

Investegate announcements from The Wistar Institute, Wistar Institute’s Maureen Murphy Named Deputy Director of the Ellen and Ronald Caplan Cancer Center

Accomplished cancer researcher supports strategy and expansion of this NCI-designated Cancer CenterPHILADELPHIA, PA, Jan. 13, 2023, has been named Deputy Director of theEllen and Ronald Caplan Cancer Centerat

A Ludwig Cancer Research study has identified a potential vulnerability in neuroblastoma tumors that might be exploited to improve treatment of the aggressive childhood cancer, which accounts for roughly 15% of all deaths from pediatric malignancies.

FEBRUARY 7, 2021, NEW YORK – A Ludwig Cancer Research study has identified a potential vulnerability in neuroblastoma tumors that might be exploited

 E-Mail IMAGE: Wistar scientists characterized an inhibitor that targets acetate metabolism in cancer cells. This molecule caused tumor growth inhibition and regression in preclinical studies, demonstrating the promise of this approach as... view more  Credit: The Wistar Institute PHILADELPHIA -- (Jan. 7, 2021) -- Scientists at The Wistar Institute characterized an inhibitor that targets acetate metabolism in cancer cells. Cancer cells use acetate metabolism to support tumor growth in...