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IMAGE: (a) cellular uptake, (b) endosomal escape, (c) GSH depletion contributed by tetrasulfide-induced GSH oxidation and zinc-mediated inhibition of GR and GSSG reduction, (d) GAPDH deactivation, (e) increased MMP, (f) mTORC1. view more
Credit: @Science China Press
Delivery of genetic molecules such as mRNA into cells is vital with important applications such as vaccine development. Various agents have been developed for mRNA delivery. However, conventional mRNA nanocarriers mainly focus on their physical interaction with mRNA molecules, or protection / delivery of mRNA, such as adjusting physical properties of nanocarriers to control binding with mRNA or cellular uptake. Moreover, effective mRNA delivery in hard-to-transfect APCs remains a challenge. The hard-to-transfect nature in APCs is partly attributed to the suppressed mRNA translation associated with the intrinsic high intracellular glutathione (GSH) level. Thus, tetrasulfide bond bridged DMONs modifie
湖南留学人员的 温馨家园 有无数动人的故事_科教 文卫_湖南频道
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赵云的官位到底高不高呢？_偏将军
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民生推动力|建设新学校、打通断头路 曲江新区持续改善民生|民生|学校-群众呼声_华商网新闻
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bill. my right hon. friend joins me in supporting the royal college of language therapy, which is rightly emphasizing central importance of speech, language and communication tackling a wide range of social issues. i will join my hon. friend in doing that. is an issue to take a close personal interest as well but anyone who worked with disabled children know the importance of speech and language therapies knows there are often not enough to provide all the health and services we need. getting those services through the statement can be tough but i agree with what he says. russell brown. thank you, mr. speaker. we know that officials from other governments were given the impression that the former defense secretary s unofficial adviser represented the u.k. government. how many people in total were misled? can you provide a list? what the hon. gentleman should do is read the report by the cabinet secretary and he will find all the details he needs about what he was do