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Introduction
It has been more than 1 year since the Covid-19 pandemic began in 2020 (1). The evolutionary origins of the SARS-CoV-2 virus can be partially traced to a lineage in bats; the closest known relative to SARS-CoV-2 (RaTG13) was found in a bat fecal sample taken from an abandoned mineshaft in Mojiang, China (2, 3). SARS-CoV-2 is proposed to have evolved via an intermediate host between bats and humans, or through natural selection in humans through direct contact with bats (2). Following a WHO-China investigation into the origins of the pandemic, a letter published in Science has pointed out analytical drawbacks of the report, that further investigatory efforts are needed to pinpoint the origin of SARS-CoV-2, and that both natural and laboratory spillover hypotheses must be taken seriously (4). Confirmation on the evolutionary origins of SARS-CoV-2 is critical for preventing future zoonotic outbreaks and pandemics.
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