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Transcriptional control of the Cryptosporidium life cycle

The parasite Cryptosporidium is a leading agent of diarrhoeal disease in young children, and a cause and consequence of chronic malnutrition1,2. There are no vaccines and only limited treatment options3. The parasite infects enterocytes, in which it engages in asexual and sexual replication4, both of which are essential to continued infection and transmission. However, their molecular mechanisms remain largely unclear5. Here we use single-cell RNA sequencing to reveal the gene expression programme of the entire Cryptosporidium parvum life cycle in culture and in infected animals. Diverging from the prevailing model6, we find support for only three intracellular stages: asexual type-I meronts, male gamonts and female gametes. We reveal a highly organized program for the assembly of components at each stage. Dissecting the underlying regulatory network, we identify the transcription factor Myb-M as the earliest determinant of male fate, in an organism that lacks genetic sex dete

How living materials from algae can best capture carbon

How living materials from algae can best capture carbon
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This yeast could protect against radiation: BC researcher

KAUST Produces Tutankhamun Perfume Oil from Algae

Middle-East Arab News and Opinion - Asharq Al-Awsat is the world’s premier pan-Arab daily newspaper, printed simultaneously each day on four continents in 14 cities

Insights from algae genes unlock mysteries of plant growth and health

Genes contain all the instructions an organism needs to live, grow, and reproduce. But identifying a gene and learning what it does are two different things. Scientists don’t know what kinds of instructions many genes contain their functions are unknown.

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