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Brain path could relieve pain as an alternative to opioids without producing dependence

Scientists at the University of Chicago have discovered a signaling pathway guided by nicotinic acetylcholine receptors (nAChRs) that could relieve pain even when tolerance to opioids was present. This mechanism did not produce dependence after treatment and could be explored to develop new drugs.
University Of Chicago Acute Pain Chronic Pain Cholinergic Circuit Ventrolateral Periaqueductal Gray

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