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Yes, there was once a Lyme Disease vaccine, and it was pulled from the market due to "poor sales" after seeming to generate symptoms that mimicked the disease

Twenty five years ago there was a vaccine marketed for Lyme disease called LYMErix, by SmithKline Beecham (later became GSK), and was approved by the FDA, but pulled from market just 4 years [...]
United States Smithkline Beecham Lyme Disease Natural News Chronic Lyme Disease Big Pharma

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