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Mutant Gene-Targeted Immunotherapy Approach Developed

share: This news release, issued by Johns Hopkins Medicine, describes a novel targeted immunotherapy approach. This new approach employs bispecific antibodies to treat cancer by eliciting a Tcell response against mutated p53. The researchers used the Highly Automated Macromolecular Crystallography (AMX) and Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines to characterize the molecular structure of the proteins. AMX and FMX are beamlines at the National Synchrotron Li...
United States Michaelb Murphy Shibin Zhou Valerie Mehl Emily Han Nickolas Papadopoulos
Source: bnl.gov

Bispecific antibodies targeting mutant RAS neoantigens

Diabodies see the unseeable RAS oncogene mutations are common in various cancers, controlling their growth and survival. Targeting mutant RAS proteins with antibodies has been unsuccessful due to low surface expression, even when targeting mutant RAS peptides presented via HLA on the surface of cancer cells. Douglass et al. used phage display to generate single-chain variable fragments (scFvs) specific for mutant RAS peptide-HLA complexes. The authors tested various bispecific, T cell–engagi...
Rock Springs United States Astra Zeneca Medimmune Amplimmune Ultramer Oligos Bristol Myers Squibb Johns Hopkins University

Mutant gene-targeted immunotherapy approach developed

Two of the three research studies -- led by Jacqueline Douglass, M.D., Ph.D. candidate at the Johns Hopkins University School of Medicine and Emily Han-Chung Hsiue, M.D., Ph.D., postdoctoral fellow at Johns Hopkins--report on a precision medicine immunotherapy approach that specifically kills cancer cells by targeting mutant protein fragments presented as antigens on the cancer cell surface. Although common across cancer types, p53 mutations have not been successfully targeted with drugs. Genet...
United States Michaelb Murphy Shibin Zhou Emily Han Nickolas Papadopoulos Michael Hwang

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