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January 19, 2024
The latest research on long COVID, includes biomarkers and paves a path for potential tests and treatments.
January 19, 2024
In persistent long COVID, elevated blood levels signal damage to various cells—red blood cells, platelets, and blood vessels.
December 11, 2023
Novartis drug iptacopan, which won its first FDA approval in early December in a rare blood disorder, has met the main goal of a pivotal test in an ultra-rare kidney disease. The small molecule’s potential to address many diseases has stirred up blockbuster expectations.
December 6, 2023
FDA approval of Novartis’s Fabhalta makes the drug the first approved oral therapy for rare blood disorder paroxysmal nocturnal hemoglobinuria. With clinical data showing superiority versus two infused AstraZeneca drugs, Novartis’s pill is well-positioned to take market share from those blockbuster products.
October 20, 2023
Chee Kay Cheung, MBCHB, MRCP, PhD, discusses unmet needs in the management of IgAN, commenting on the need for new medication and highlighting budesonide and SGLT2 inhibitors.
September 11, 2023
Immunology expert discusses the complement system, immunogenicity challenges in AAV-mediated gene therapy, and more
September 1, 2023
Context-dependent role of complement in cancer could provide novel prognostic biomarkers to inform treatment decisions
August 31, 2023
Context-dependent role of complement in cancer could provide novel prognostic biomarkers to inform treatment decisions
August 24, 2023
Research led by investigators at Ghent University in Belgium showed dysregulation of the complement part of the immune system, regulated by the pro-inflammatory protein interleukin (IL)-6, is a key driver of severe COVID-19 and a good target for drugs to treat the effects of the disease.
February 21, 2023
The immune system is essential to protect organisms from internal and external threats. The rapidly acting, non-specific innate immune system includes complement, which initiates an inflammatory cascade and can form pores in the membranes of target cells to induce cell lysis. Regulation of protein homeostasis (proteostasis) is essential for normal cellular and organismal function, and has been implicated in processes controlling immunity and infection. Chaperones are key players in maintaining p...