Page 19 - Confidence Interval News Today

Elevated serum endotrophin levels, but not urinary endotrophin levels, predict increased risk of kidney complications and mortality in type 1 diabetes.

1. In this randomized controlled trial, treatment with pegozafermin improved fibrosis in patients with nonalcoholic steatohepatitis (NASH). 2. Treatment with pegozafermin led to increased rates of NASH resolution. Evidence Rating Level: 1 (Excellent) Study Rundown: NASH is a disease characterized by hepatic inflammation and excess fat accumulation with or without fibrosis of the liver. Pegozafermin

1. In this cross-sectional study, the proportion of Chinese adults with self-reported type 2 diabetes who achieved a guideline-recommended HbA1c target was 64.1%. 2. The proportion of Chinse adults with self-reported type 2 diabetes who achieved a guideline-recommended blood pressure was 22.2%. Evidence Rating Level: 1 (Excellent) Study Rundown: More than one-quarter of the Chinese

1. In this cohort study, using generic versus brand-name fluticasone-salmeterol was associated with similar outcomes in chronic obstructive pulmonary disease (COPD) patients. 2. Using generic versus brand-name fluticasone-salmeterol was associated with no significant difference in the incidence of COPD exacerbations or pneumonia hospitalizations. Evidence Rating Level: 1 (Excellent) Study Rundown: Chronic obstructive pulmonary disease is

1. In this randomized controlled trial, adjunctive treatment with escitalopram or bupropion XL for 52 weeks was not superior to eight weeks in preventing relapse of mood episodes among patients with bipolar I depression. 2. The rates of adverse events were comparable across both approaches. Evidence Rating Level: 2 (Good) Study Rundown: Bipolar I disorder

Taking adequate measures to reflect the nature of the process

1. In this randomized controlled trial, the elective NaV1.8 inhibitor VX-548 reduced acute pain over 48 hours following abdominoplasty and bunionectomy. 2. The main adverse events associated with VX-548 use were headaches and constipation. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute pain, especially following traumas and surgical procedures, remains an area of unmet medical

New data from a dose-finding trial suggests the aldosterone synthase inhibitor lorundrostat could find a role in the management of resistant or uncontrolled hypertension.

1. In this pooled analysis of randomized controlled trials, low-dose glucocorticoids taken over a two-year period did not increase patient blood pressure. 2. Low-dose glucocorticoid use was associated with an increase in weight of one kilogram on average. Evidence Rating Level: 1 (Excellent) Study Rundown: Glucocorticoids are commonly used in the management of rheumatoid arthritis (RA), though

HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Sept. 12, 2023 (GLOBE NEWSWIRE) -- HUTCHMED (China) Limited (“HUTCHMED”) (Nasdaq/AIM: HCM, HKEX: 13) today...