Page 23 - Confidence Interval News Today

1. In this randomized controlled trial, in adults with hypogonadism and cardiovascular risk factors, testosterone did not reduce the incidence of major adverse cardiac events (MACE) compared to a control. 2. Arrhythmias, atrial fibrillation, acute kidney injury, and pulmonary embolism occurred more frequently in the testosterone group. Evidence Rating Level: 1 (Excellent) Study Rundown: Male

1. In this randomized controlled trial, the E-MOTIVE bundle, consisting of early detection and treatment of postpartum hemorrhage, was associated with a lower risk of complications than usual care. 2. The E-MOTIVE treatment bundle also resulted in higher detection rates of postpartum hemorrhage and treatment adherence compared to usual care. Evidence Rating Level: 1 (Excellent)

1. In this randomized controlled trial, cyclophosphamide-tacrolimus-mycophenolate mofetil was associated with lower rates of graft-versus-host disease (GVHD) compared to tacrolimus-methotrexate in patients undergoing hematopoietic stem-cell transplantation (HSCT). 2. There were no significant differences between groups for overall survival. Evidence Rating Level: 1 (Excellent) Study Rundown: GVHD is a major complication of HSCT. The combination of

1. In this case-control study, adults with mpox were less likely to have been partially or fully vaccinated with the JYNNEOS vaccine compared to those without. 2. The adjusted effectiveness of the JYNNEOS vaccination amongst participants with two doses was estimated to be 66%. Evidence Rating Level: 2 (Good) Study Rundown: Mpox is a viral

An analysis of NHANES data is offering clinicians an overview of associations between hyperuricemia and gout with increased risk of mortality in patients with heart failure.

1. In this randomized controlled trial, patients with ulcerative colitis taking mirikizumab had higher rates of clinical remission compared to those taking a placebo. 2. Opportunistic infections occurred more frequently in the mirikizumab group. Evidence Rating Level: 1 (Excellent) Study Rundown: Recent clinical trials and approval of monoclonal antibody treatments for ulcerative colitis suggest interleukin-23

Welcome to the 2 Minute Medicine Podcast, summarizing the latest medical studies, curated and written by practicing physicians. On this podcast, twice a month, we cover the latest in healthcare news and research evidence. Our episode is live! Episode Description We begin this episode by discussing our article of the week from the New England

1. In this randomized controlled trial, the Eat, Sleep, Console approach resulted in a significantly shortened time to medical readiness for discharge in neonates with opioid withdrawal syndrome. 2. There was no significant difference between usual care and the Eat, Sleep, Console approach in the incidence of adverse outcomes. Evidence Rating Level: 1 (Excellent) Study

1. In this randomized controlled trial, cyclophosphamide-tacrolimus-mycophenolate mofetil was associated with lower rates of graft-versus-host disease (GVHD) compared to tacrolimus-methotrexate in patients undergoing hematopoietic stem-cell transplantation (HSCT). 2. There were no significant differences between groups for overall survival. Evidence Rating Level: 1 (Excellent) Study Rundown: GVHD is a major complication of HSCT. The combination of

1. In this randomized controlled trial of patients with atrial fibrillation who had an acute ischemic stroke, early versus late anticoagulation resulted in a comparable incidence of 30-day adverse events. 2. Risk of death from any cause or disability was similar at 90 days between the early and late anticoagulation groups. Evidence Rating Level: 1