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Characterizing idiopathic CD4 lymphocytopenia 30-years after its initial description

1. In this observational study, idiopathic CD4 lymphocytopenia (ICL) was associated with an increased risk of opportunistic infections, malignancy, and poor response to coronavirus disease 2019 (COVID-19) vaccination. 2. The most common opportunistic infections were related to human papillomavirus, cryptococcosis, molluscum contagiosum, and nontuberculosis mycobacterial disease. Evidence Rating Level: 2 (Good) Study Rundown: CD4 T-cell
Minute Medicine Inc Rating Level Confidence Interval Cd4 Lymphocytopenia Chronic Disease Human Papillomavirus

Four-Year Outcomes from Phase 3 CheckMate -9LA Trial Show Durable, Long-Term Survival with Opdivo (nivolumab) Plus Yervoy (ipilimumab) with Two Cycles of Chemotherapy for Patients with Metastatic Non-Small Cell Lung Cancer

Patients treated with dual immunotherapy-based combination demonstrate sustained clinical benefits after four years vs. chemotherapy alone, with magnitude of benefit more pronounced amongst patient... | June 4, 2023
United States South Korea Bristol Myers Squibb Davidp Carbone Drug Administration Company Opdivo

Four-Year Outcomes from Phase 3 CheckMate -9LA Trial Show Durable, Long-Term Survival with Opdivo (n

Patients treated with dual immunotherapy-based combination demonstrate sustained clinical benefits after four years vs. chemotherapy alone, with magnitude of benefit more pronounced amongst patient subgroups with high unmet needsLate-breaking data to be presented during the 2023 American Society of Clinical Oncology...
United States Davidp Carbone Thoracic Oncology Center American Society Of Clinical Oncology Ohio State University Comprehensive Cancer Center Solove Research Institute

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Epicutaneous immunotherapy is effective at desensitizing toddlers to peanut allergens

1. In this randomized controlled trial, an epicutaneous patch containing peanut protein was more effective than a placebo in raising the threshold dose required to trigger an allergic reaction to peanuts in toddlers. 2. The epicutaneous immunotherapy patch was associated with higher rates of treatment-related anaphylaxis than the placebo. Evidence Rating Level: 1 (Excellent) Study
Minute Medicine Inc Rating Level Confidence Interval

GLP-1 receptor agonists lower adverse cardiac event risk in veterans with type 2 diabetes

1. In this retrospective cohort study, glucagon-like peptide-1 receptor agonists (GLP1RA) were associated with a lower risk of major adverse cardiac events (MACE) in veterans with type 2 diabetes compared to dipeptidyl peptidase-4 inhibitors (DPP4i). 2. The addition of a sodium-glucose cotransporter-2 inhibitor (SGLT2i) was not associated with a primary reduction in major adverse cardiac
Misuse Of Observational Research Veterans Health Administration Minute Medicine Inc Rating Level Comparative Effectiveness Diabetes Drugs

HIV status does not impact mpox treatment with tecovirimat

1. In this retrospective study, tecovirimat was effective for treating mpox regardless of human immunodeficiency virus (HIV) status. 2. The incidence of adverse events was low regardless of HIV status in patients with severe mpox. Evidence Rating Level: 2 (Good) Study Rundown: Mpox is a zoonotic orthopoxvirus first described in the 1950s-1970s. In May 2022,
New York United States Minute Medicine Inc Centre For Disease Control Rating Level Population Genomic Screening

#VisualAbstract: RSVpreF vaccine prevents RSV-associated illness in adults aged 60+

1. In this randomized controlled trial, respiratory syncytial virus prefusion F protein-based vaccine (RSVpreF) prevented RSV-associated lower respiratory tract illness in adults 60+ years of age. 2. The RSVpreF vaccine also was associated with significantly decreased rates of acute respiratory illness in adults aged 60+. Evidence Rating Level: 1 (Excellent) Study Rundown: RSV is a common cause
Rating Level Confidence Interval Older Adults Respiratory Syncytial Virus Rsv Rsv Prefusionf Protein Vaccine

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