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The Janssen Pharmaceutical Companies - U.S. FDA Approves IMBRUVICA (ibrutinib) as First and Only BTKi Treatment for Pediatric Patients with Chronic Graft-Versus-Host Disease

HORSHAM, PA - The Janssen Pharmaceutical Companies of Johnson & Johnson announced that the U.S. Food and Drug Administration has approved IMBRUVICA for the treatment of pediatric patients one... | August 25, 2022
Craig Tendler Christie Corbett Susan Stewart Janssen Research None Of The Janssen Pharmaceutical Companies Slate Development

Janssen Marks First Approval Worldwide for TECVAYLI?(teclistamab) with EC Authorisation of First-in-Class Bispecific Antibody for the Treatment of Patients with Multiple Myeloma

Teclistamab, an off-the-shelf (ready to use) subcutaneously administered therapy, induced deep and rapid responses in triple-class exposed patients with relapsed and refractory multiple myeloma1 The
United States Jenni Mildon Williamn Hait Maria Victoria Mateos Peter Lebowitz Edmond Chan

BNT162b2 vaccine reduces rates of COVID-19 omicron variant infection in children

1. This national cohort study from Singapore showed a significant reduction in SARS-CoV-2 omicron variant infections in children vaccinated with BNT162b2 as compared to unvaccinated children. 2. Vaccination with BNT162b2 in children is also associated with reduced hospitalization due to SARS-CoV-2 omicron variant infection. Evidence Rating Level: 1 (Excellent) Study Rundown: The omicron variant of
Ministry Of Health Rating Level Confidence Interval

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Cinpanemab therapy does not prevent Parkinson's disease progression

1. Cinpanemab did not show clinical efficacy in preventing early Parkinson’s disease (PD) progression compared to placebo. 2. There was no difference in imaging results of dopamine transporters between cinpanemab and placebo groups. Evidence Rating Level: 1 (Excellent) Study Rundown: PD is the second most prevalent neurodegenerative disease worldwide. The mainstay of treatment is dopamine
Movement Disorder Rating Level Movement Disorder Society Sponsored Unified Parkinson Disease Rating Scale Confidence Interval

Prasinezumab therapy does not affect Parkinson's Disease progression

1. Prasinezumab had no meaningful effect on global or imaging measures of Parkinson’s disease progression. 2. Prasinezumab therapy was associated with increased infusion reactions compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Aggregated a-synuclein is a main factor in the pathogenesis of Parkinson’s disease. Prasinezumab was designed as a monoclonal antibody to bind
United States Movement Disorder Rating Level Randomized Trial Focused Ultrasound Subthalamotomy Movement Disorder Society Sponsored

Germline mutations in CIDEB confer protection from liver disease

1. Rare mutations in CIDEB are associated with a decreased risk of developing liver cirrhosis. 2. Further, rare mutations in CIDEB are associated with a decreased risk of nonalcoholic fatty liver disease. Evidence Rating Level: 1 (Excellent) Study Rundown: For patients with obesity and nonalcoholic fatty liver disease, the risk of progression to steatohepatitis and
Geisinger Health System Rating Level Liver Disease Associated United Kingdom Biobank Penn Medicine Biobank Mount Sinai

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