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Improved long-term survival with resynchronization versus defibrillation for heart failure

1. In this randomized controlled trial, the incidence of death was lower in heart failure patients who received cardiac-resynchronization therapy (CRT) versus those who received implantable cardioverter-defibrillators (ICD). 2. The time until death was longer in patients who received cardiac-resynchronization therapy than those who received implantable cardioverter-defibrillators. Evidence Rating Level: 1 (Excellent) Study Rundown: CRT
York Heart Association Minute Medicine Inc Rating Level Ambulatory Heart Failure Trial New York Heart Association Confidence Interval

Low-dose calcium noninferior to high-dose calcium in reducing rates of pre-eclampsia

1. In two randomized, noninferiority trials, low-dose calcium in pregnant women with low dietary calcium intake was noninferior to high-dose supplementation in reducing the risk of pre-eclampsia. 2. Low-dose calcium was noninferior to high-dose calcium in reducing the risk of live preterm birth in the trial in India but not in Tanzania. Evidence Rating Level:
World Health Organization Minute Medicine Inc Rating Level Confidence Interval High Dose Calcium Low Dose Calcium

Apixaban lowers the risk of stroke in subclinical atrial fibrillation

1. In this randomized controlled trial, apixaban lowered the risk of stroke or systemic embolism significantly more than aspirin in patients with subclinical atrial fibrillation. 2. Apixaban was associated with a higher risk of major bleeding than aspirin. Evidence Rating Level: 1 (Excellent) Study Rundown: Symptomatic atrial fibrillation is a leading cause of stroke and stroke-related
International Society On Thrombosis Minute Medicine Inc Rating Level Atrial High Rate International Society Hazard Ratio

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Subcutaneous Nivolumab (nivolumab and hyaluronidase) Shows Noninferiority Compared to Intravenous Opdivo (nivolumab) in Advanced or Metastatic Clear Cell Renal Cell Carcinoma in CheckMate -67T Trial

CheckMate -67T is the first Phase 3 trial of the subcutaneous formulation of Opdivo to evaluate and demonstrate noninferior pharmacokinetics, efficacy and safety vs. its intravenous...
United States South Korea Gina Fusaro Saby George Bristol Myers Squibb Roswell Park Comprehensive Cancer Center

Bristol Myers Squibb - Eight-Year Data for Opdivo Plus Yervoy Continue to Demonstrate Longest Survival Benefit vs. Sunitinib Reported in Patients with Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

PRINCETON - Bristol Myers Squibb today announced that Opdivo plus Yervoy continued to demonstrate long-term survival results in the Phase 3 CheckMate -214 trial, reducing the risk of death by 28%...
United States South Korea Nizar Tannir Dana Walker Bristol Myers Squibb Drug Administration

Liquefied petroleum gas stove use during pregnancy does not reduce stunting in infants

1. In this randomized controlled trial, replacing biomass stoves with those using liquefied petroleum gas (LPG) during pregnancy did not reduce stunting in infants at one year despite reductions in household air pollution. 2. There was no appreciable difference in stunting in infants at six months between the biomass cookstove and liquefied petroleum gas cookstove
World Health Organization Household Air Pollution Intervention Network Minute Medicine Inc Rating Level Multicenter Growth Reference Study Confidence Interval

Opdivo® (nivolumab) in Combination with CABOMETYX® (cabozantinib) Demonstrates Long-Term Survival Benefits After Four Years of Follow-Up in the CheckMate -9ER Trial in First-Line Advanced Renal Cell Carcinoma

Opdivo in combination with CABOMETYX reduced the risk of death by 23% in the first-line treatment of advanced renal cell carcinoma vs. sunitinib Four-year results demonstrating continued benefits...
United States South Korea Dana Walker Amy Peterson Bristol Myers Squibb Maria Teresa Bourlon

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