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Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance

SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 provides guidance for clinical trial protocol writing. However, neither the original guidance nor its extensions adequately cover the features of early phase dose-finding trials. The SPIRIT Dose-finding Extension (DEFINE) statement is a new guideline that provides recommendations for essential items that should be provided in the protocols of these trials. It details extensions to the SPIRIT 2013 guidance, incorpora...
Glasgow City United Kingdom West Midlands United Kingdom General United States Daiichi Sankyo
Source: bmj.com

April 2022 Events From the Ocean Beach Green Center

All events are online and free unless stated otherwise. Every Saturday 10:30 am. Climate Mobilization Coalition Zoom Meeting. April 2nd, 9th, 16th, 23rd, and 30th. April 6th Wednesday 5:30 pm - 7 pm Public Surveillance vs. Personal Privacy April 7th Thursday 1 pm - 2 pm Achieving Green Infrastructure in San Diego April 9th Saturday…
Allied Gardens United States Lemon Grove United Kingdom El Prado National City
Source: obrag.org

Plasma D-dimer found noninferior to serum CRP in diagnosis of PJI

Published results showed plasma D-dimer was noninferior to serum C-reactive protein and erythrocyte sedimentation rate in the diagnosis of periprosthetic joint infection.“This study demonstrated that plasma D-dimer had comparable diagnostic accuracy to traditional inflammatory markers, such as CRP and [erythrocyte sedimentation rate] ESR, in the diagnosis of PJI,” Saad Tarabichi, MD,
Saad Tarabichi International Consensus Meeting Rothman Orthopaedic Institute Consensus Meeting
Source: healio.com

Plasma D-dimer measurement can provide useful information when diagnosing periprosthetic joint infection

Measurement of plasma D-dimer levels – a test more commonly used to detect blood-clotting disorders – can provide useful information when making the difficult diagnosis of periprosthetic joint infection (PJI), reports a study in The Journal of Bone & Joint Surgery.
United States Javad Parvizi Emily Henderson International Consensus Meeting Wolters Kluwer Rothman Orthopaedic Institute At Thomas Jefferson University

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Yacht Club de Monaco: Yachting: Monaco Smart & Sustainable Marina, Innovative Solutions for a Virtuous Action

MONACO, Sept. 22, 2022 (GLOBE NEWSWIRE) -- For the 2nd Monaco Smart & Sustainable Marina Rendezvous, M3 (Monaco Marina Management), the Monegasque consultancy specialised in development, management and
United Kingdom Jean Michel Wilmotte Barbara Sanicola Robin Knox Johnston Kostenloser Wertpapierhandel Olivier Wenden

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