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Science News | Scientists Turn Up Spotlight on Cells in Tissues So RNA Could Explain Disease and Biology

Get latest articles and stories on Science at LatestLY. A new advance overcomes present limitations in spatial transcriptomics with a DNA nanotechnology-driven method called Light-Seq. Light-Seq allows researchers to geotag the full repertoire of RNA sequences with unique DNA barcodes exclusive to a few cells of interest. These target cells are selected using light under a microscope via a fast and effective photocrosslinking process, and their RNAs made available to next-generation sequencing w...
United States Baden Wüberg Ninning Liu Joe Biden Jocelyn Josie Kishi Constance Cepko

Light-Seq technology for barcoding and deep-sequencing selected cell populations in tissues

Under the microscope, researchers often observe different cell types organizing themselves in peculiar patterns within tissues, or sometimes a rare cell type that stands out by occupying a unique position, exhibiting an unusual shape, or expressing a specific biomarker molecule.
United States Baden Wüberg Constance Cepko Ninning Liu Donald Ingber Sinem Saka

Gene therapy may offer a new approach to preserving vision in people with retinitis pigmentosa

Gene therapy may offer a new approach to preserving vision in people with retinitis pigmentosa A gene therapy protects eye cells in mice with a rare disorder that causes vision loss, especially when used in combination with other gene therapies, shows a study published today in eLife. The findings suggest that this therapy, whether used alone or in combination with other gene therapies that boost eye health, may offer a new approach to preserving vision in people with retinitis pigmentosa or o...
United States Constance Cepko Yunlu Xue Emily Henderson Harvard Medical School Howard Hughes Institute Investigator

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Gene therapy shows promise in treating rare eye disease in mice

 E-Mail A gene therapy protects eye cells in mice with a rare disorder that causes vision loss, especially when used in combination with other gene therapies, shows a study published today in eLife. The findings suggest that this therapy, whether used alone or in combination with other gene therapies that boost eye health, may offer a new approach to preserving vision in people with retinitis pigmentosa or other conditions that cause vision loss. Retinitis pigmentosa is a slowly progressive d...
United States Ekaterina Pesheva Constance Cepko Yunlu Xue Emily Packer Howard Hughes Institute Investigator Constance Cepko

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