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Science News | Scientists Turn Up Spotlight on Cells in Tissues So RNA Could Explain Disease and Biology

Get latest articles and stories on Science at LatestLY. A new advance overcomes present limitations in spatial transcriptomics with a DNA nanotechnology-driven method called Light-Seq. Light-Seq allows researchers to geotag the full repertoire of RNA sequences with unique DNA barcodes exclusive to a few cells of interest. These target cells are selected using light under a microscope via a fast and effective photocrosslinking process, and their RNAs made available to next-generation sequencing w...
United States Baden Wüberg Ninning Liu Joe Biden Jocelyn Josie Kishi Constance Cepko

Light-Seq technology for barcoding and deep-sequencing selected cell populations in tissues

Under the microscope, researchers often observe different cell types organizing themselves in peculiar patterns within tissues, or sometimes a rare cell type that stands out by occupying a unique position, exhibiting an unusual shape, or expressing a specific biomarker molecule.
United States Baden Wüberg Constance Cepko Ninning Liu Donald Ingber Sinem Saka

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