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Iptacopan Reduces Proteinuria, Demonstrates Benefit in C3 Glomerulopathy

In the APPEAR-C3G trial, iptacopan reduced proteinuria by 35.1% in patients with C3 glomerulopathy, with Novartis planning regulatory submissions for C3G before the end of 2024.
G Steering Committee Member David Kavanagh European Renal Association Congress Foundation Trust David Kavanagh Faculty Of Medical Sciences At Newcastle University David Kavanagh Steering Committee Member David Kavanagh

Novartis presents latest Phase III Fabhalta® (iptacopan) data in C3 glomerulopathy (C3G) showing clinically meaningful and statistically significant 35.1% proteinuria reduction vs. placebo

Secondary endpoint data for estimated glomerular filtration rate (eGFR) showed numerical improvement over 6 months vs. placebo1; additional 6-month open-label...
Czech Republic United States Parag Mahanti David Soergel Prnewswire Novartis Marianne Silkj

Novartis Pharma AG: Novartis presents latest Phase III Fabhalta® (iptacopan) data in C3 glomerulopathy (C3G) showing clinically meaningful and statistically significant 35.1% proteinuria reduction vs. placebo

Secondary endpoint data for estimated glomerular filtration rate (eGFR) showed numerical improvement over 6 months vs. placebo1; additional 6-month open-label data to be presented at a future medical meeting2
United States Czech Republic Imke Kappes Marlena Abdinoor David Soergel Michael Meo

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