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Antidepressants Not Superior to Psychotherapy for Severe Depression

On Wednesday, JAMA Psychiatry released a meta-analysis comparing the results of cognitive-behavioral therapy and antidepressant medication in severely depressed populations. Currently, many practice guidelines suggest that antidepressants be used over psychotherapy for major depressive disorder. The analysis, however, found that โ€œpatients with more severe depression were no more likely to require medications to improve than patients with less severe depression.โ€
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