Dong Lab News Today

Dong Lab/UCLA Branch-like axons (blue) connect with neurons (green) in the last stage of the cortico-basal ganglia-thalamo-cortical loop, a neural

7 P2X receptors carry out many important functions in the central and peripheral nervous system. 8,9 Compelling evidence has shown that P2X3, P2X4 and P2X7 receptors are involved in the pathogenesis of chronic pain. 10 P2X7R exists in neurons and glial cells of the nervous system, but is mainly expressed in cells of immune origin such as monocytes, macrophages, and microglia. 11 The absence of P2X7R can completely eliminate the inflammatory and neuropathic hypersensitivity to both mechanical an...