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Androgen receptor signaling affects response to targeted therapy in people with melanoma

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers from The University of Texas MD Anderson Cancer Center showed in a study published today in Nature.
United States Timothy Heffernan Jennifer Wargo Joseph Marszalek Emily Henderson Md Anderson Translational Research To Advance Therapeutics

Exscientia plc: Exscientia Reports Topline Data From EXS-21546 Phase 1a Study Demonstrating Targeted A2A Receptor Signaling Inhibition in Healthy Volunteers

Clinical data builds upon body of evidence suggesting EXS-21546 is a highly potent and selective A2AR antagonist with low CNS exposure Exscientia anticipates initiating Phase 1b/2 in patients with
United States Amanda Galgay David Hallett Sara Sherman Evotec Se Frankfurt Stock Exchange Frankfurt Stock Exchange

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Fezolinetant reduces the frequency and severity of menopausal hot flashes, study finds

Fezolinetant significantly reduced the frequency and severity of moderate-to-severe vasomotor symptoms (VMS), or hot flashes, associated with menopause, according to a Phase 3 industry-sponsored study being presented Saturday at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.
Genevieve Neal Perry Emily Henderson Astellas Pharma Inc Endocrine Society University Of North Carolina School Medicine Distinguished Professor

Researchers demonstrate the feasibility of pancreatic beta-cell, target-specific CAR-Treg treatment for T1D

Researchers have successfully treated type 1 diabetes in mice using pancreatic beta-cell, target-specific, chimeric antigen-receptor (CAR) regulatory T cells (Tregs), and demonstrated the feasibility of their approach to treat the human condition according to data being presented Monday, June 13 at ENDO 2022, the Endocrine Society's annual meeting in Atlanta, Ga.
United States Juan Carlos Jaume Emily Henderson Endocrine Society Endocrine Research Ce Division Of Endocrinology

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