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Study investigates the production of a virosome-based COVID-19 vaccine candidate

In a new study, different signal peptides, baculovirus transfer vectors, cell lines, infection techniques, and formulation buffers were investigated with the purpose of building a scalable bioprocess to generate high-quality S protein for incorporation in a virosome-based COVID-19 vaccine candidate.
Leonid Altman Shutterstock World Health Organization Insect Cells High Yield Production Image Credit Coronavirus Disease Covid 19

Comparison of neutralizing antibody response following SARS-CoV-2 booster vaccination with breakthrough infection

A new study examined the serological immune responses and antibody-dependent cell-mediated phagocytosis in individuals who had either received two doses of a standard vaccine regime, a booster dose following the regime, or a breakthrough infection following vaccination.
World Health Organization Coronavirus Disease Coronavirus Disease Covid 19 Ars Cov 2 Amino Acid Ngiotensin Converting Enzyme 2

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Mayo Clinic researchers devise a combination approach to more effectively target solid tumors

Researchers at Mayo Clinic's Center for Individualized Medicine have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors.
Emily Henderson Researchers At Mayo Clinic Center Virus Therapy Program Mayo Clinic Cancer Center Mayo Clinic Individualized Medicine

Researchers identify certain gene regulation signatures in CAR T-resistant leukemia patients

Acute lymphoblastic leukemia (ALL) cells from patients whose cancers did not respond to CD19-targeted CAR T therapy had gene regulation signatures that could potentially facilitate treatment resistance, according to results presented at the AACR Annual Meeting 2022, held April 8-13.
Javed Khan Rebecca Gardner Rimas Orentas Katherine Masih Emily Henderson National Cancer Institute

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

Researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.
Glial Cell Derived Neurotrophic Factor Significance Analysis Contaminant Repository Human Protein Atlas Activate Formins Coronavirus Disease Covid 19

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