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Molecular dynamic simulations unveil conformational dynamics of SARS-CoV-2 spike protein RBD and ACE2 receptor

Researchers presented a systematic analysis of the affinity and conformational dynamics between the binding of SARS-CoV-2 receptor-binding domain spike protein and the host angiotensin-converting enzyme 2 receptor.
Akarat Jarernthanawut Shutterstock University Of Para Research Square Federal University Spike Protein Image Credit

Vaccine-induced antibody response to SARS-CoV-2 Omicron variant in patients with B cell malignancies with and without active B cell-targeted therapy

Researchers have determined the effect of booster immunization on the levels of antibodies generated, against SARS-CoV-2 variants, including the Omicron strain, in cancer patients with or without active B cell-targeted therapy.
Ohio State University Comprehensive Cancer Center Corona Borealis Ohio State University Comprehensive Cancer B Cell Coronavirus Disease Covid 19 Ars Cov 2

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Combination therapy shows promising results in patients with recurrent ER-positive endometrial cancer

A combination therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in 75% of patients with recurrent or persistent estrogen receptor- (ER-) positive endometrial cancer, results from a recent clinical trial show.
Dana Farber Panagiotis Konstantinopoulos Emily Henderson Dana Farber Cancer Institute Society Of Gynecologic Oncology Gynecologic Oncology Panagiotis Konstantinopoulos

Trial shows safety and immunogenicity of immunotherapy with chemoradiation in cervical cancer patients

A Phase I/Ib trial conducted by the National Cancer Institute (NCI) National Clinical Trials Network (NCTN) group NRG Oncology, NRG-GY017, concluded that the addition of the immunotherapy drug atezolizumab prior to and concurrently given with chemoradiation (CRT) treatment was safe for women with node-positive, locally advanced cervical cancer.
United States San Diego Jyoti Mayadev Emily Henderson University Of California National Clinical Trials Network

Excessive neuropeptide secretion in the lungs can lead to fluid buildup and poor oxygenation

COVID-19 has put a spotlight on the pulmonary and nervous systems, but there is still much to learn about how they interact. Researchers at University of California San Diego School of Medicine recently explored this relationship in the context of a childhood lung disease, but their findings may also apply to COVID-19 symptoms.
San Diego United States University Of California San Diego Xin Sun Jinhao Xu Emily Henderson

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