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New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Researchers at University Hospitals Seidman Cancer Center and Case Western Reserve University have developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers that triples the targeted antigens on cancer cells โ€“ a "back up" approach that promises to greatly reduce the potential for antigen escape currently found in CAR T therapies that solely target CD19.
Stan Gerson Emily Henderson National Center Nature Communications Case Comprehensive Cancer Center Drug Administration

Scientists describe a smell sensory map in fruit flies

The distinctive smell of a flower.. the unmistakable aroma of coffeeโ€ฆ the dangers linked with inhaling smoke fumes. Sensory systems have evolved to provide us with immediate, finely tuned information about the world around us, whether they are colors processed through our visual system or certain pitches interpreted through our hearing.
United States San Diego University Of California San Diego Johnatan Aljadeff Chih Ying Su Emily Henderson

Research supports the need for a 3rd mRNA COVID vaccine in patients taking immunosuppressants

New research posted to the medRxiv* preprint server finds patients with immune-mediated inflammatory diseases undergoing anti-TNF therapy had the greatest reduction of antibody levels three months after vaccination. In addition, they had weaker neutralization responses towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.
Image Credit Coronavirus Disease Covid 19 Covid 19 Inflammatory Disease Ars Cov 2 Evere Acute Respiratory

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Experimental immunotherapy could help treat some people with metastatic breast cancer

An experimental form of immunotherapy that uses an individual's own tumor-fighting immune cells could potentially be used to treat people with metastatic breast cancer, according to results from an ongoing clinical trial led by researchers at the National Cancer Institute's Center for Cancer Research, part of the National Institutes of Health.
Stevena Rosenberg Emily Henderson Cancer Research National Cancer Institute National Institutes Of Health Surgery Branch

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.
South Africa Transmembrane Serine Protease Coronavirus Disease Covid 19 Ars Cov 2 Covid 19 Evere Acute Respiratory

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