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Red blood cells play a much larger role in the immune system than previously thought

New research has revealed that red blood cells function as critical immune sensors by binding cell-free DNA, called nucleic acid, present in the body's circulation during sepsis and COVID-19, and that this DNA-binding capability triggers their removal from circulation, driving inflammation and anemia during severe illness and playing a much larger role in the immune system than previously thought.
Nilam Mangalmurti Emily Henderson Peer Reviewed Medical Research Program Health Affairs National Institutes Of Health Office Of The

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New findings may help widen therapeutic interventions for B-cell acute lymphoblastic leukemia

A retrospective study led by Northwestern Medicine investigators found that the chimeric antigen receptor (CAR) T-cell immunotherapy drug tisagenlecleucel demonstrated safety and efficacy in pediatric patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-cell ALL), even when the drug doesn't meet the FDA's strict manufacturing standards.
United States Emily Henderson Jenna Rossoff Roberth Lurie Comprehensive Cancer Center Northwestern University Division Of Hematology

An investigation of three SARS-CoV-2 mRNA doses in multiple sclerosis vaccine non-responders

A clinical study by a team of scientists from Norway aimed to assess the immunogenicity and safety of a third dose of COVID-19 mRNA vaccine in MS patients treated with anti-CD20 therapy or fingolimod. A preprint version of the study, which is yet to undergo peer review, is available on the medRxiv* server.
Shital Sarah Ahaley Image Credit Coronavirus Disease Covid 19 Multiple Sclerosis Ars Cov 2 Immune Response

Study highlights the need to follow recommended COVID-19 vaccine timelines in pregnant, lactating women

A new study indicates that the two-dose immunization schedule for COVID-19 mRNA vaccines ultimately stimulates comparable antibody responses in pregnant, lactating, and nonpregnant women of reproductive age, but key antibody functions kick in more slowly in pregnant and lactating women following the first dose.
United States Andrea Edlow Emily Henderson Reproductive Biology At Harvard Medical School Massachusetts General Hospital Science Translational Medicine

Research uncovers a new human sensory ability to detect sugars in the mouth

Most everyone understands that a major role of our sense of taste is to inform us when sugar is present in foods and beverages by eliciting sweetness on our tongues. A study led by the Monell Chemical Senses Center, published this month in PLOS ONE, identifies a new human sensory ability to detect sugars in the mouth with a molecular calorie detector, of sorts.
Paul Breslin Yoshiaki Yokoo Tadahiro Ohkuri Lindaj Flammer Anilet Tharp Akiko Izumi

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