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Research reveals 3D structure of cell receptor with critical role in health and disease

Cells communicate with their environment via receptors on their surface. When a protein approaches these receptors, they can pass along a message to the inside of the cell, for example the instruction to grow which can lead to tumor formation.
United States Emily Henderson National Cancer Research Institute Tokyo Inflammation Research Savvas Savvides Center Memorial Sloan Kettering Cancer Center New York

New study finds SARS-CoV-2 causes retinal infection

Can coronavirus disease 2019 (COVID-19) affect the eye? New research suggests the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the eye and infect photoreceptor and retinal ganglion cells. In addition, SARS-CoV-2 infection increases the expression of several inflammatory genes, including the cytokine interleukin 33 (IL33), which is linked to COVID-19 disease and retinal degeneration.
Jocelyn Solis Moreiraoct Jocelyn Solis Moreira Coronavirus Disease Covid 19 Retinal Degeneration Ars Cov 2 Ene Expression

Anti-rheumatic drug as a potential candidate for treating COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces inflammatory cytokine storms. But an FDA-approved anti-rheumatic drug, Auranofin, used to treat autoimmune and infectious diseases, may also help serve as an antiviral treatment for COVID-19 infection.
Karine Sonzogni Desautels Momar Ndao Jocelyn Solis Moreiraoct Jocelyn Solis Moreira Research Institute Mcgill University Health Centre

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How long does natural immunity produced by SARS-CoV-2 infection last?

A new study posted to the bioRxiv* preprint server followed the adaptive immune response in convalescent patients from Swedish and Italian cohortsโ€”which had earlier shown long-lasting adaptive immune responses to the G614 strainโ€”for 15 months. Here, specific antibody levels and neutralizing antibody titers were tested against variants of concern (VOCs).
Nidhi Saha S Specific Igm S Specific Iga S Specific Igg Coronavirus Disease Covid 19 Ars Cov 2

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

Oncotarget published "Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients" which reported that LMNB2 is a chromatin remodeling protein that also plays a role in eukaryotic cell proliferation by organizing the nuclear membrane during mitosis.
United States Wafiks El Deiry Emily Henderson El Deiry Research Team Oncotarget Research Output Lifespan Health System

Researchers uncover how cancer cells use sugar residue to evade the immune system

A team of South Dakota State University chemistry researchers uncovered how cancer cells utilize a simple sugar residue to disguise themselves from the immune system. What they learned will help scientists develop more effective cancer therapeutics.
United States South Dakota State University South Dakota United Kingdom Stanford University Susan Grabenstein Roh

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