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A team of Australian researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI), the Doherty Institute, and the Kirby Institute have identified neutralizing nanobody cocktails that block the SARS-CoV-2 virus from entering cells in pre-clinical models.

Triple mutation in SARS-CoV-2 seen in second wave of COVID-19 in India Researchers sequenced the viral genome from samples in the state of Maharashtra and found a unique combination of three mutations that suggest the SARS-CoV-2 virus is continually evolving to evade the human immune response. With the COVID-19 pandemic continuing to spread in several parts of the world, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is evolving to evade our immune system. Several new variant...

Two Major Studies Have Connected One Key Hormone to Breast Cancer CLARE WATSON 27 APRIL 2021 An unusual but ubiquitous hormone called prolactin, which plays a vital role in producing milk during pregnancy, could also be a major driver of breast cancer, two new studies have shown.   The findings are the latest in a long line of research from a lab led by cancer pathologist Charles Clevenger from Virginia Commonwealth University, who has been trying to untangle prolactins precise role in bre...

SARS-CoV-2 antibody response robust in nursing home residents after Pfizer-BioNTech vaccine The first wave of the coronavirus disease 2019 (COVID-19) pandemic was associated with significantly higher mortality among older people. As a result, this age group, particularly the vulnerable community living in long-term care facilities or nursing homes, was prioritized in vaccine rollouts in most countries. However, with the waning of the immune response, it is not clear if these older people respon...

Study characterizes anti-inflammatory effect of strawberry geranium on the skin Strawberry geranium ( Saxifraga stolonifera) has been used in Japan as a herbal medicine to treat wounds and swelling, and continues to be an ingredient in food and cosmetics. Pharmacological studies have shown that extracts of strawberry geranium have antioxidant and antitumor activities. However, the anti-inflammatory effect of strawberry geranium on the skin had not been well characterized. This study, first-auth...

The Native Antigen Company, part of LGC Clinical Diagnostics and one of the world’s leading suppliers of reagents that enables research into diagnostics and vaccines for emerging and endemic infectious diseases, today announced the launch of its SARS-CoV-2 Neutralisation Assay Development Kit. The kit can be used to identify and qualitatively assess the ability of antibodies to neutralize SARS-CoV-2-receptor binding, to support research into variants and their effects on natural and vaccine-i...

Metabolic testing of COVID-19 patients through skin imprints The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), shows no sign of abating soon. In fact, the recent surge of cases caused by new and potentially more lethal variants of the virus, with immune evasion capabilities, threatens to overwhelm healthcare systems in many countries, even as vaccines are being rolled out in many. There is, therefore, a great need to understand ...

Humoral immunity developed by DNA vaccine INO-4800 is effective against SARS-CoV-2 variants A team of international scientists recently demonstrated that antibodies generated in response to the DNA vaccine INO-4800 can effectively neutralize some of the recently emerged variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as G614, 501Y.V1, and 501Y.V2. The study is currently available on the Background The coronavirus disease 2019 (COVID-19) vaccines currently rolling...

Novel mRNA delivery vehicle provides alternative to LNPs for SARS-CoV-2 vaccines Researchers in the United States have developed an alternative messenger RNA (mRNA) delivery platform to the lipid nanoparticles that are currently used in vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The lipid nanoparticle (LNP) delivery vehicles have inherent immunostimulatory properties that can induce adverse events ...

Could a tuna-derived protein inhibit SARS-CoV-2? Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause respiratory distress and even death in severe cases. The disease manifested is called COVID-19 (coronavirus disease 2019). To date, no specific antiviral drug is available to treat the highly virulent SARS-CoV-2 infections in humans. A recent study in the journal Food Chemistrydraws attention to the need for finding nutritional supplements with potential SARS-C...