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Researchers develop computational model to predict changes in SARS-CoV-2’s viral fitness Through advantageous mutations that can occur at the virus’s spike protein, tests have shown that the emergence of several new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can help the virus to infect human host cells more efficiently. Despite various mitigation measures, the coronavirus disease 2019 (COVID-19) pandemic continues, with more than 138.7 million people infected ...

Cell receptor neuropilin-1 offers a promising anti-tumor strategy Cancer is an insidious disease that, despite being around for centuries, is still very difficult to diagnose and treat. Thus, cancer has been the focus much research in the biomedical fields. Today, with research methods advancing rapidly and the base pool of researchers growing constantly, our fundamental understanding of the mechanisms of cancer formation and proliferation have increased, and new more promising treatment avenue...

Modeling study suggests how different SARS-CoV-2 mutations prevent antibody binding Using three classes of antibodies, researchers modeled their binding to the SARS-CoV-2 virus spike protein. They found binding to key residues in current mutations changes how the spike protein moves and can lead to binding resistance. The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adopts several conformations when it binds to host receptors. Antibodies against the virus of...

Curcumin nanosystems could be powerful COVID-19 therapeutics With new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging, the coronavirus disease 2019 (COVID-19) pandemic is far from over. While the global vaccine rollout has moved at an impressive speed, the search for new safe, effective, and targeted therapies is still on. Now, a new study in Biomedicine and Pharmacotherapy reviews the potential for curcumin, a natural alkaloid derived from turmeric, and nanos...

SARS-CoV-2 can alter bone marrow macrophage (BMM)-to-osteoclast differentiation, study finds The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is primarily a respiratory illness. However, as the pandemic evolves, scientists have observed a range of different ways that the virus can affect the body. Alongside the lungs, SARS-CoV-2 has been seen to affect other organs, including the heart, brain and gastrointestinal tract...

Researchers probe intriguing interaction between sugars and the SARS-CoV-2 spike protein The causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic is the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This highly infectious virus belongs to the coronavirus family. Another virus from the same family is SARS-CoV-1, which is less infectious than SARS-CoV-2. SARS-CoV-1 and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses which infect the epi...

Feeling famished all the time regardless of how much you eat is a struggle experienced by many people. This problem can be dealt with by making dietary or lifestyle changes, but in some cases, it could be a sign of certain medical conditions. When not treated, this constant hunger can lead to severe obesity. A new study, published in Science on April 15, has the potential to pave the way for drugs that can "turn off the hunger switch" in the brain. Researchers at the Weizmann Institute of Sci...

Updated Moderna vaccines neutralize South African SARS-CoV-2 variant in mice Researchers in the United States have conducted a pre-clinical study demonstrating the efficacy of two updated versions of the Moderna mRNA-1273 vaccine against variants of severe acute respiratory syndrome coronavirus 2 – the agent that causes coronavirus disease 2019 (COVID-19). The updated vaccine candidates include the monovalent mRNA-1273.351, which is designed to target the B.1.351 variant that emerged in South...

Researchers in the United States have identified 95 high-frequency mutations in the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that threaten to compromise the efficacy of current and future vaccines and antibody therapies for coronavirus disease 2019 (COVID-19).

Experimental evidence that ADAM17 inhibition prevents severe COVID-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that is contagious in humans. It is the causal agent of the ongoing coronavirus 2019 (COVID-19) pandemic. This virus causes a mild to severe infection and has claimed over 2.95 million lives worldwide. SARS-CoV-2 is the successor to SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. Both SARS and SARS-CoV-2...