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Fatty liver disease susceptibility: study identifies interaction between estrogen receptor and genetic variant in women

Researchers pursued evidence of whether the interaction between the patatin-like phospholipase domain-containing 3 p.I148M variant and the female sex at the genetic and molecular level explains why premenopausal women remain protected against fatty liver disease, while a rapidly progressive disease ensues in some peri- and postmenopausal women.
Nature Medicine Liver Biopsy Cohort Fatty Liver Liver Disease Hepatocellular Carcinoma Liver Transplantation

New form of cellular immunotherapy shows promise against brain tumors in mice

Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) successfully tested a new form of cellular immunotherapy against brain tumors in mice for the first time.
Baden Wรผberg Danielle Ellis Michael Platten Lukas Bunse German Cancer Research Center Deutsches Krebsforschungszentrum University Medical Center Mannheim

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most currently known sarbecoviruses.
Andrii Vodolazhskyi Shutterstock National Center Nature Biomedical Engineering Biotechnology Information Coronavirus Disease Covid 19 Covid 19

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Tirzepatide outshines other treatments in lowering blood sugar and weight for type 2 diabetes patients

Meta-analysis finds tirzepatide to be the most effective GLP-1 receptor agonist for glucose and weight control in type 2 diabetes patients. The study suggests tirzepatide could be preferable in initial stages of the disease, while other GLP-1 receptor agonists combined with insulin are equally effective for long-term diabetics.
Clinical Medicine Image Credit Blood Sugar Type 2 Diabetes Body Mass Index Diabetes Mellitus

Rare genetic variants involved in male-pattern hair loss identified

A receding hairline, a total loss of hair from the crown, and ultimately, the classical horseshoe-shaped pattern of baldness: Previous research into male pattern hair loss, also termed androgenetic alopecia, has implicated multiple common genetic variants.
Nordrhein Westfalen Stefanie Heilmann Heimbach Sabrina Henne Danielle Ellis University Of Bonn University Hospital Of Bonn

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