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An ActRIIA fusion protein got FDA approved for PAH treatment

On March 26th, the US FDA granted approval for Merckโ€™s WINREVAIRโ„ข (sotatercept-csrk), marking a significant milestone in pulmonary arterial hypertension (PAH) treatment. PAH, characterized by elevated blood pressure in the arteries connecting the heart and lungs, poses a grave risk of heart failure.
Maria Osipova Implications Across Disease Blood Pressure Heart Failure Pulmonary Arterial Hypertension

Newly discovered molecule may be a potential therapeutic target for triple-negative breast cancer

A team of researchers from Hiroshima University has discovered a molecule that promotes the production of cancer cells. This molecule may prove to be a potential therapeutic target in the treatment of triple-negative breast cancer, an aggressive form of breast cancer.
Kazunori Imaizumi Atsushi Saito Taichi Ito Nayuta Nakazawa Yasunao Kamikawa Analysis Center

AI-based analysis uncovers two plant extracts with potential as GLP-1 agonist weight loss pills

Two plant compounds with potential as GLP-1 agonist weight loss pills have been identified in an AI (artificial intelligence)-based study, the European Congress on Obesity (ECO 2024) (Venice 12-15 May), will hear.
Elena Murcia Performance Computing Research Group European Congress On Obesity Disorders Research Unit Catholic University Of Murcia European Congress

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Heart at risk from ARDS: Inflammatory responses fuel cardiovascular complications

Research highlights the inflammatory impacts of ARDS on the heart, underscoring the role of immune responses in cardiovascular complications from viral infections, including COVID-19, and emphasizes the potential of TNF-ฮฑ neutralizing therapy to mitigate these effects.
United States Kateryna Kon Image Credit Massachusetts General Hospital Acute Respiratory Distress Syndrome Blood Pressure

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.
Jeffreyi Cohen National Institute Of Allergy National Institutes Of Health Nih National Institute Of Allergy National Institute Infectious Diseases

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