Page 29 - Ene Expression News Today

Scientists tend to view substance addiction as primarily a disease of the brain. When we enjoy sex, food, music, or hobbies, regions of our brain within the reward pathway are flooded with pleasure-inducing dopamine.

In a recent study posted to the bioRxiv* preprint server, researchers identified a novel antiviral pathway different from the interferon (IFN) pathway that inhibited poxvirus(es) replication.

Traffic noise may play an essential role in the development and deterioration of ischemic heart disease. Researchers from the Cardiology Department at the University Medical Center Mainz now discovered that noise exposure(average sound pressure level 72 dB; peak level 85 dB) up to 4d resulted in pro-inflammatory aortic gene expression in mice.

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like gene regulation has been greatly enhanced by the development of a process termed PETEOS—short for peptidyl-tRNA enrichment using organic extraction and silica adsorption.

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

Researchers identified serological Hepatitis C virus (HCV) signatures and human immunodeficiency virus (HIV) signatures through the secondary utilization of ribonucleic acid sequencing (RNA-seq) analysis data among previous and existing smokers with or without COPD (chronic obstructive pulmonary disease).

Children have largely avoided severe COVID-19 symptoms because they have a strong initial 'innate' immune reaction that quickly defeats the virus.

A study published in the journal PNAS reveals that the gut microbiome stabilizes the synchronization between gut and brain circadian rhythms.

Researchers at the University of Pittsburgh School of Medicine, U.S. present the first evidence of 12-hour cycles of gene activity in the human brain. Publishing in the open access journal PLOS Biology on January 24th, the study led by Madeline R. Scott also reveals that some of those 12-hour rhythms are missing or altered in the postmortem brains of patients with schizophrenia.

Researchers assess the effectiveness of multiple senolytic interventions in removing senescent cells in aged human brain organoids.