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Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have found that measuring activation of immune-system B cells may be better than measuring either T-cell activation or the total number of immune cells in and around a tumor, called tumor-infiltrating lymphocytes (TILs), in predicting whether HER2-positive breast cancer responds to treatment.
Charles Perou Aranzazu Fernandez Martinez Lisaa Carey Emily Henderson Lineberger Comprehensive Cancer Center Lineberger Breast Cancer Research Program

Study shows the clinical utility of amniotic fluid cells RNA-sequencing in prenatal rare disease diagnosis

A clinical research team from the Department of Paediatrics and Adolescent Medicine and the Department of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) leads the discovery of applying amniotic fluid cells obtained during 16-24 weeks of pregnancy as a novel sample type for RNA-sequencing in prenatal diagnosis to help more families with tailored clinical management.
United States Hong Kong Anita Kan Sik Yau Kelvin Chan Yuen Kwong Mianne Lee Anna Kwong Ka Yee

Scientists find key reason for ongoing loss of smell in long-COVID

In a recent study published in the journal Science Translational Medicine, researchers reported that long-term anosmia following coronavirus disease 2019 (COVID-19) could be a result of persistent T-cell mediated inflammation occurring in the olfactory epithelium even after the elimination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the olfactory tissue.
Nicole Rerk Science Translational Medicine Discovery Industry Focus Coronavirus Disease Covid 19 Covid 19 Ene Expression

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Xanthan gum-based fluid thickener can lower blood glucose levels after eating, study shows

Type 2 diabetes mellitus is a common lifestyle disease that is prevalent worldwide. It can often lead to complications, such as diseases of the heart, and increased risk of death, but preventive measures, such as a healthy diet, can reduce these risks.
Haruka Tohara Emily Henderson Diabetes Mellitus Gastrointestinal Tract Ene Expression Metabolic Disorders

Research uncovers a new way to boost the effectiveness of RNA therapies

Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells-;cells that control your heartbeat-;can "fight back" against therapies to biologically correct abnormal heartbeat rates.
Eugenio Cingolani Eduardo Marb Emily Henderson Cardiogenetics Program Smidt Heart Institute Marks Siegel Family Foundation Distinguished Professor

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