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Discovery could lead to new mantle cell lymphoma drugs

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.
United States Forkhead Biotherapeutics Hongwu Zheng Jihye Paik Emily Henderson Weill Cornell Medicine

Study reveals mechanism by which malignant cells shut down anti-cancer immune responses

A Ludwig Cancer Research study has revealed a single protein expressed at high levels by cancer cells across a broad range of malignancies that erects a multifaceted barrier to anti-cancer immune responses in mouse models of cancer and so shields tumors from immune detection and destruction.
Sadegh Saghafinia Agnieszka Chryplewicz Douglas Hanahan Ludwig Lausanne Douglas Hanahan Opna Bio Qiqun Zeng

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Research highlights an understudied aspect of Alzheimer's disease

Memory loss is often the first sign of Alzheimer's disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of worsening damage to brain tissues. Toxic clusters of proteins first concentrate in the temporal lobes of the brain -; the memory area -; before spreading to parts of the brain important for thinking and planning.
Barbara Burton David Holtzman Briana Gordon Aylin Dincer Reubenm Morriss Emily Henderson

SARS-CoV-2 RNA levels, IFN-1, ISGs, and NF-κB gene responses within the respiratory tract of mild and severe COVID-19 patients

Researchers characterized the expression of IFN-1 and IFN-2, ISGs, and NF-κB in the upper respiratory tracts of patients with mild and severe COVID-19, to understand innate immune responses to SARS-CoV-2 infections.
United States United States National Institute Of Health United States National Institute Coronavirus Disease Covid 19 Covid 19 Ars Cov 2

Unique cellular signature can accurately detect obstructive sleep apnea in children

Researchers from the University of Missouri School of Medicine have discovered how obstructive sleep apnea (OSA) changes the profiles of immune cells in the blood, leading to a unique cellular signature that can accurately detect obstructive sleep apnea in children.
Leila Kheirandish Gozal Harryl Smith Kylie Cataldo David Gozal Irene Cortese Justin Hummel

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