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Key Alzheimer's gene alters the way cholesterol moves around the brain, research finds

A gene recognized as the strongest risk factor for Alzheimer's disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology reports.
United States Joel Blanchard Jose Davila Velderrain Li Huei Tsai Emily Henderson Ronaldm Loeb Center

Protein complex may present strong therapeutic target for lethal breast cancer

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that a protein complex that governs gene expression (called CoREST) sometimes gets rewired during breast cancer to help estrogen receptor positive (ER+) tumors resist endocrine therapies and become more aggressive.
United States Ramiro Verdun Lluis Morey Liliana Garcia Martinez Emily Henderson Researchers At Sylvester Comprehensive Cancer Center

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Pregnancy and birthing have long-lasting effects on the maternal brain

Pregnancy and birthing have profound, often long-lasting, effects on brain physiology, mood and behavior. New findings on the neurobiology of the maternal experience were presented at Neuroscience 2022, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.
United States Janace Gifford Jamie Maguire Emily Henderson Icahn School Of Medicine At Mount Sinai Tufts University School Of Medicine

Circadian disruption induces weight gain through changes in gut microbiota

In a recent study published in the journal Molecular Metabolism, researchers investigated the impact of environmental and genetic disruptions of the circadian rhythms on the peripheral circadian clock synchronization and microbiome oscillations in the gastrointestinal tract.
Alpha Tauri Molecular Metabolism Original Article Genetic Genomics Industry Focus Circadian Rhythm Gastrointestinal Tract

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