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MIT scientists discover how molecular clusters interact with chromosomes in the nucleus

A cell stores all of its genetic material in its nucleus, in the form of chromosomes, but that's not all that's tucked away in there. The nucleus is also home to small bodies called nucleoli -; clusters of proteins and RNA that help build ribosomes.
Yifeng Qi Emily Henderson Broad Institute Of Harvard Nature Communications Laubach Career Development Associate Professor Of Chemistry Betty Moore Foundation

Novel protein regulator of tumor angiogenesis may be a therapeutic target for difficult-to-treat cancers

A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.
United States Mira Palizban James Kehler Rolland Reinbold Daniela Mazzaccaro Gianfranco Bellipanni

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the mechanism behind regulated splicing of large constitutive exons which are rich in disordered regions, and their potential involvement in the assembly of transcription factors.
Akio Masuda Emily Henderson Nagoya University Associate Professor Akio Masuda Ene Expression Transcription Factors

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Researchers decipher when and why T cells become non-responsive to immunotherapy

Non-small cell lung cancer is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by reinvigorating a subset of immune cells called T cells, which are "exhausted" and have stopped working.
United States San Francisco Mary Margaret Clausen Stefani Spranger Brendan Horton Emily Henderson

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