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Deciphering the role of Th2-multipotent progenitor cells in chronic allergic inflammation

Currently, most therapies for allergic diseases require lifelong treatment. Allergic reactions, characterized by ongoing (type 2) inflammation in response to chronic antigen exposure, underlie many chronic diseases in humans, including asthma, atopic dermatitis, ulcerative colitis and more.

Massachusetts
United-states
Patrick-brennan
Radomir-kratchmarov
Division-of-allergy
Mass-general-brigham
Massachusetts-general-hospital
Mass-eye
Chronic
Nflammation
Llergy
Ntigen

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

Taipei
T-ai-pei
Taiwan
Vijesh-kumar-yadav
Chi-tai-yeh
Tung-cheng-chang
Kuang-tai-kuo
Ying-wei-chen
Shiue-wei-lai
Taipei-medical-university-shuang
National-taitung-university
Taipei-medical-university

Extra fingers and double hearts: Scientists decode how tiny mutations can derail development

Our genomes provide the instructions for proper growth and development. Millions of genomic switches, known as enhancers, control the location and timing of gene expression, which in turn ensures the correct proteins are made in the right cells at the right time throughout our lives.

California
United-states
San-diego
University-of-california-san-diego
American
Gemma-farley
Agnieszka-dantonio-chronowska
Paige-steffen
Simran-jandu
Jessica-grudzien
Adam-klie
Sophia-le

Sam Altman's Life Extension Guy Warns of Injections That Cause Wild Tumor Growth

OpenAI CEO Sam Altman has invested a whopping $180 million in a startup that's looking for novel ways to extend human longevity. As Bloomberg, which recently got an insider look at the company, reports, the company called Retro Biosciences has an unusual way of conducting its research, and is investigating not just one area of […]

Jeff-bezos
Peter-thiel
Sam-altman
Joe-betts
Bloomberg
Retro-biosciences
Joe-betts-lacroix
Sheng-ding
Retro-biosciences
Loomberg
Issues
Transcription-factors

Scientists uncover key to enhancing cancer-killing T cells

T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion.

Jordy-saravia
Peipei-zhou
Shondra-pruett-miller
Hongbo-chi
Hongling-huang
Nicole-chapman
Jonp-connelly
Xiang-sun
Zhao-shi
Cancer-center-support-grant
National-institutes-of-health
Jude-children-research-hospital

Atlas of cancer's hidden rules: Unveiling the transcriptomic and epigenetic secrets across 11 tumors

Researchers have mapped the complex epigenetic and transcriptomic landscape of cancer, revealing key regulatory elements across 11 tumor types that could unlock new insights into cancer progression and metastasis.

Cancer
Chromatin
Ell
Hromosome
Strogen
Ene
Ene-expression
Enes
Enetic
Growth-factor
Alignant

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