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New testing technology can accurately differentiate between viral and bacterial infections When patients complain of coughing, runny nose, sneezing and fever, doctors are often stumped because they have no fundamental tool to identify the source of the respiratory symptoms and guide appropriate treatments. That tool might finally be on its way. In a study proving feasibility, researchers at Duke Health showed that their testing technology can accurately distinguish between a viral and a bacteri...

A recent article in the Centers for Disease Control and Prevention (CDC)’s Emerging Infectious Diseases reveals that the last of these was probably due to the introduction of a new variant from Nepal. This novel variant had been circulating in the community for about a month before the last outbreak was reported.

A new study describes a synthetic peptide used as a platform to generate protective adaptive cellular immunity to the virus in rhesus macaques, which are the gold standard for preclinical testing in humans.

Study reveals a hidden role of circulating microRNA as a driver of SARS-CoV-2 infection In a methodological tour-de-force study, a large group of researchers from the USA and the United Kingdom analyzed patient transcriptomic data in-depth and discovered a circulating microRNA (miR-2392) that is directly implicated in the severe acute respiratory syndrome coronavirus 2 (SARS ‑ 2) machinery during the infection process. Human-to-human transmission of SARS-CoV-2 triggered an ongoing pandemic of...

Celastrol shows potential anti-SARS-CoV-2 activity On the 11th of March 2020, the World Health Organization (WHO) announced Coronavirus Disease 2019 (COVID-19) to be a pandemic. This disease is highly infectious and is caused by a novel positive-stranded β-coronavirus, namely, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Globally, this virus has had a devastating effect on public health and the economy. Scientists believe that only the discovery of effective vaccines and poten...

About two million years ago, a second gene network emerged that regulated social cooperation and self-direction. We could translate this as the capacity for self-control for mutual benefit. The third and final network, which emerged 100,000 years ago, was (and continues to be) related to creative self-awareness.  The research study revealed that the oldest network of genes, for emotional reactivity , was almost identical in chimpanzees, Neanderthals and Homo sapiens. The unique 267 genes, wh...

Interfering RNA nanoparticles could be a potential COVID-19 therapy Study shows lipid nanoparticle-based siRNA is potent in suppressing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – in cells as well as in mice models. COVID-19 cases continue to increase all over the world. Several vaccines have now been approved and are being administered. However, with new variants of the virus emerging, there have been questi...

Genetic variants that impact protein binding in immune cells can cause autoimmune diseases Apr 16 2021 Certain genetic variants that cause modified protein binding in immune cells, are also seen in those at high risk of some autoimmune diseases, new research has found.   Scientists from the Wellcome Sanger Institute, Josep Carreras Leukaemia Research Institute in Spain, and the MRC London Institute of Medical Sciences (LMS) found that certain genetic variants, which alter the binding ability o...

Study may lead to new therapies for patients suffering from Duchenne muscular dystrophy A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease. Titled, "A Stromal Progenitor and ILC2 Niche Promotes Muscle Eosinophilia and Fibrosis-Associated Gene Expression," the study was published today in ...

Study reveals how DNA segments function in cells A new study co-authored by University of Colorado Cancer Center researcher Srinivas Ramachandran, PhD, shows how DNA segments known as enhancers function in cells. The paper published last month in Molecular Cell highlighted the work from Ramachandran, along with Satyanarayan Rao, both part of the Department of Biochemistry and Molecular Genetics at the CU School of Medicine, and Kami Ahmad from the Fred Hutchinson Cancer Research Center. Enhanc...