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A CRISPR on-off switch for genes controls expression without altering DNA

April 12, 2021 -- A new gene silencing tool allows scientists to switch genes on and off without altering genetic sequences. The tool, described in a paper published in Cell on April 9, uses a modified CRISPR-Cas9 system to introduce reversible epigenetic changes that control gene expression. The classic CRISPR-Cas9 system led to an explosion in gene editing studies since it was first developed almost a decade ago. It became quickly popular thanks to its ease of use compared to previous gene e...
United States San Francisco Luke Gilbert Jonathan Weissman University Of California Jennifer Cook Chrysos Whitehead Institute For Biomedical Research

Autism may be Detected by Sperm Epigenetics

Autism may be Detected by Sperm Epigenetics by Karishma Abhishek on  January 14, 2021 at 12:14 PM Biomarkers in human sperm can indicate if a father can inherit autism spectrum disorder to his children. The biomarkers are found to be epigenetic - molecular changes in factors regulating genome activity, such as gene expression independent of DNA sequence. It can be passed down to future generations, as per a study published in the journal Clinical Epigenetics. This particul...
Autism Spectrum Disorder Epigenetic Changes Molecular Changes Genomic Activity மன இறுக்கம் மன இறுக்கம் ஸ்பெக்ட்ரம் கோளாறு

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